Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization
نویسندگان
چکیده
منابع مشابه
Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization.
Piwi proteins such as Drosophila Aubergine (Aub) and mouse Miwi are essential for germline development and for primordial germ cell (PGC) specification. They bind piRNAs and contain symmetrically dimethylated arginines (sDMAs), catalyzed by dPRMT5. PGC specification in Drosophila requires maternal inheritance of cytoplasmic factors, including Aub, dPRMT5, and Tudor (Tud), that are concentrated ...
متن کاملSpatiotemporal localization of germ plasm RNAs during zebrafish oogenesis
In zebrafish, primordial germ cells (PGCs) are determined by a specialized maternal cytoplasm, the germ plasm, which forms at the distal ends of the cleavage furrows in 4-cell embryos. The germ plasm includes maternal mRNAs from the germline-specific genes such as vasa and nanos1, and vegetally localized dazl RNA is also incorporated into the germ plasm. However, little is known about the distr...
متن کاملTargeting and Anchoring Tudor in the Pole Plasm of the Drosophila Oocyte
BACKGROUND Germline formation is a highly regulated process in all organisms. In Drosophila embryos germ cells are specified by the pole plasm, a specialized cytoplasmic region containing polar granules. Components of these granules are also present in the perinuclear ring surrounding nurse cells, the nuage. Two such molecules are the Vasa and Tudor proteins. How Tudor localizes and is maintain...
متن کاملWhat Is Germ Plasm?
Special Articles: Normal Human Stromata as Antigens for Complement Fixation in the Sera of Patients with Relapsing livax Malaria: DR. MICHAEL HEIDELBERGER and MANFRED M. MAYER. Induction of Leukemia in Mice: D. ARTHUR KIRSCHBAUM and DR. HENRY S. KAPLAN. The Neutralization in Vitro of Avian Pneumoencephalitis Virus by Newcastle Disease Immune Serum: D. J. R. BEACH. The Isolation of the St. Louis...
متن کاملElective affinities: a Tudor-Aubergine tale of germline partnership.
In Drosophila melanogaster and many other metazoans, the specification of germ cells requires cytoplasmic inheritance of maternally synthesized RNA and protein determinants, which are assembled in electron-dense cytoplasmic structures known as germ or polar granules, found at the posterior end of the oocytes. Recent studies have shown that the formation of germ granules is dependent on the inte...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: RNA
سال: 2009
ISSN: 1355-8382
DOI: 10.1261/rna.1869710